This morning, like most weekday mornings, I dropped off our older son at his kindergarten by bicycle.

There was a significant difference between this morning and the previous mornings of the last few weeks: the temperature had dropped by about 10 degrees to as low as -4 degrees celsius. This sudden change, together with the fact that I was not wearing gloves this morning made me remember the 2021 nobel prize laureates David Julius and  Ardem Patapoutian and their discoveries of receptors for temperature and touch.
As my last assignment of the year finished earlier this week, I had some time on my hands and put together this illustration of TRPM8 (transient receptor potential melastatin 8), the primary detector of environmental cold (DOI: 10.1126/science.aax6672, 6O6A).